Module 4: Antibiotics and Their Use

These free OCR A Level Biology Antibiotics and Their Use revision notes have been written for specification point 4.1.1(n).

Antibiotics: Importance and Use

Antibiotics are medicines that either kill bacteria or inhibit their growth. 

Penicillin, the first antibiotic, was discovered by Alexander Fleming in 1928 from the fungus Penicillium notatum.


Antibiotic Resistance

Antibiotic resistance occurs when bacteria evolve mechanisms to survive exposure to antibiotics. This poses a serious risk to public health, as it can make infections:

  • Harder to treat
  • More likely to spread
  • More likely to cause complications or death

MRSA (methicillin-resistant Staphylococcus aureus) is a major example of a resistant “superbug” that has become prevalent in hospitals, making routine surgery more dangerous.

The factors which accelerate the evolution of antibiotic resistance include:

FactorExplanation
Overuse of antibioticsIncreases selection pressure for resistance
Incomplete courses of treatmentLeaves behind resistant bacteria
Use in agricultureAntibiotics given to livestock may spread resistance genes to human pathogens

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